Thessaloniki is Greece's second major economic, industrial, commercial and political centre, and a major transportation hub for the rest of southeastern Europe; its commercial port is also of great importance for Greece and the southeastern European hinterland. The city is renowned for its festivals, events and vibrant cultural life in general, and is considered to be Greece's cultural capital. Events such as the Thessaloniki International Trade Fair, the Thessaloniki International Film Festival, and the Thessaloniki Song Festival are held annually, while the city also hosts the largest bi-annual meeting of the Greek diaspora. Thessaloniki was the 2014 European Youth Capital.

The city of Thessaloniki was founded in 315 BC by Cassander of Macedon. An important metropolis by the Roman period, Thessaloniki was the second largest and wealthiest city of the Byzantine Empire. It was conquered by the Ottomans in 1430, and passed from the Ottoman Empire to modern Greece on 8 November 1912.

Because Thessaloniki remained under Ottoman rule for about 100 years more than southern Greece, it has retained a lot of its Eastern character, including its culinary tastes. Spices in particular play an important role in the cuisine of Thessaloniki, something which is not true to the same degree about Greece's southern regions. Thessaloniki's Ladadika borough is a particularly busy area in regards to Thessalonian cuisine, with most tavernas serving traditional meze and other such culinary delights.